10 Comments
User's avatar
J Altazar's avatar

Only Science would bring people together over Mitochondria. Going in to listen. 🎧

Liface's avatar

> bowl of awesome peanuts-only peanut butter

I think this may be a brand new sentence!

Isabel Bermudez's avatar

Amazing to hear your interaction with the uber driver about TBI! This patient population has no available pharmacological treatments, and psychedelics are an excellent candidate. The combination of reduced inflammation and increased metaplasticity slows disease progression while enabling therapeutic intervention. Neuroplastogen-augmented cognitive/metabolic rehabilitation

Jeffrey's avatar

The question remains: to fight off an inflammation costs MGR; to engage in several bouts of intense training costs MGR. Wherein lies the mitochondrial difference?

Ober Camelia Diana's avatar

One of the most interesting podcasts, in which you not only shines but also conveys exactly what you feel, with humility and gratitude for everything you’ve experienced, learned, and understood.

Jonathan Reams's avatar

I can't help but be happy this is getting such attention. I listened to the podcast and signed up here. I also recall reading about mitochondria in the early 70's in Madeleine L'Engle's classic kids book, A Wrinkle in Time.

Jeffrey's avatar

I have some trouble with the seeming contradiction inherent in creating mitochondrial flow: on the one hand decreasing unnecessary energy-robbing things (usually related to undesirable stress); on the other, seeking energy-demanding things which challenge us, provide the essential resistance to make us grow (e.g. being hungry, being out of breath, cognitive challenges). The only way I perceive a way to differentiate between the two in your discussion is that the former, “energy robbing” is a) undesirable and b) stuff that makes us feel bad; whereas the “positive energy producing” resistance is a) consciously embraced and b) stuff that makes us feel good, what in the old days was dubbed constructive vs. non-constructive challenges, a not very scientific differentiation. Can you offer a better handle on it?

Jeffrey's avatar

Forgive me, a reply to myself. Could this be it? Maintainance of energy transformation at low cost, i.e. brief bouts of consciously embraced, targeted resistance, followed by recovery, generate the best ongoing energy production and flow.

Ganapathi Kandasamy's avatar

This work is truly a masterpiece. It is inspiring to see how scientific methods and tools can be effectively leveraged to advance human health. What is more important in the world than taking care of our health and systematically transferring this knowledge to future generations. Integrating such essential health education into school and college curricula would be a meaningful step toward building a healthier society.