When you inhibit Complex I or III, the inner mitochondrial membrane (IMM) depolarizes. Pro-inflammatory cytokines do not drop. Why? Because the inflammatory cascade is an evolutionary backup plan (atavism). It runs on primitive, disordered, high-entropy pathways like cytoplasm glycolysis and fermentation. It requires zero magnetic alignment. The High-Voltage Handshake: To synthesize and secrete IL-10, a Breg must actively maintain an exceptionally low-resistance state (éR) across its electron transport chain. It requires intact electron flow to generate the precise electromagnetic and Ultra-weak Photon Emission (UPE) fields that instruct the nucleus to open the IL-10 gene promoter. The Selective Collapse: The moment the IMM drops its negative voltage, the cell ALSO loses its capacity for isotopic fractionation. Heavy deuterium (²H) floods the matrix, the water lattice de-structures into thick sludge, and the high-energy cost of maintaining peace can no longer be met. The cell can still scream (inflammation), but it can no longer enforce order (IL-10). Regarding lupus you did not take the physics lesson far enough. Thioredoxin is not just a chemical antioxidant; it is a vital protein semiconductor that acts as an electron donor pool for the cell. Lowering the Resistance Set Point: When exogenous thioredoxin is introduced into these depolarized Bregs, it manually floods the system with missing electrons. Because light and field stabilization can only interact with electrons, this influx of electronic charge density instantly stabilizes the radical pair spins at Complex I and III. This is what Vitamin D from the sun does. It slows ECT before CCO. Restoring the Battery: The localized spin chaos is quieted, allowing the IMM to remagnetize, rebuild its negative exclusion zone water battery, and repolarize its membrane. The éR set point drops, the Breg numbers recover, and the cell can finally resume its high-energy production of IL-10. This mechanism explains why modern non-native EMFs (nnEMF) and artificial blue-pumped LEDs are the direct, upstream drivers of the global explosion in autoimmune conditions like lupus, rheumatoid arthritis, and Graves' disease. High-frequency wireless radiation and screen glare scramble the Zeeman splitting effect in the mitochondrial heme proteins. This destroys the seasonal calibration of the PER2 lipid raft mechanics. The Calcium Flood: As the lipid rafts lose their structural tensegrity, voltage-gated calcium channels leak constantly. Calcium ions flood the matrix. Because calcium is a heavy dopant atom, an unregulated flood inside the mitochondrion physically binds to and blocks the electronic active sites of Complex I and Complex III. The Immune Trap: This environmental blockade induces the exact same depolarization seen in the drug studies. The resistance-lowering, anti-inflammatory arm collapses across your entire white blood cell pool. Your immune system remains stuck in a permanent, uncoupled state of chronic alarm, unable to manufacture the T-Regs or Bregs needed to establish peripheral tolerance.
Why do you still have questions? Because you have a centralized perspective looking for drugs to fix a physics problem. Reversing the Autoimmune Resistance begins with the following: You cannot heal an autoimmune condition by using centralized pharmaceuticals to suppress the remaining pro-inflammatory signals. That is an act of thermodynamic futility that further drains an already empty cellular battery. To turn the IL-10 production line back on, you must manually rewrite the electronic terrain of your immune cells: Rebuild the Thioredoxin Electron Pool with Morning Light: Step into the unfiltered morning UV-A and Near-Infrared sunlight barefoot to ground at the same time. The 43% infrared spectrum directly expands the negative exclusion zones (EZ) of your immune cell water, lowering fluid viscosity and naturally donating the raw electrons needed to restore thioredoxin activity without synthetic supplementation. Eradicate the Complex I & III Field Blockade: Create an ironclad magnetic sanctuary during sleep. Turning off all Wi-Fi, cell phone transmitters, and smart appliances eliminates the artificial fields that force calcium to leak into the mitochondrial matrix. This allows your heme networks to realign with the Earth's natural geomagnetic baseline, giving your Complex I and III the quiet quantum environment they require to rebuild their voltage, drop their resistance, and natively command the immune system to stand down.
Yes and go back to incandescent lighting, use IF lights, forest bathing but try to see how the genetic personal profile links to the mitochondria and energy resistance. Nevertheless, much food for thought.
This is an insightful and helpful viewpoint. Resistance is the issue. Low level stressors good; high level stressors bad (mitohormesis). Cytokines are not the bogeyman. They are the messengers. Carb restriction, coupled with intermittent fasting, provides the low level stressors necessary to switch between burning glucose, fats, and ketones for energy (metabolic flexibility).
Thank you for such an open-minded look at inflammation, and for keeping the hypotheses close to actual observations.
I keep wondering whether IL-10 might also be telling us something about what happens before the mitochondrion - whether substrate reaches the cell at the right place and time in the first place.
There are two potential approaches: adopt a diet favouring monounsaturated fats over the stiff ceramides that impair mitochondria, and repair of the control points that let cells produce IL-10 and respond to it.
The key is to lower the resistance. Any low-carb or no-carb approach with intermittent fasting would be helpful. The goal is to lower the glucose and force low level stressors toward metabolic flexibility (switching between burning glucose, fats and ketones for energy).
We usually describe IL-10 as the anti-inflammatory brake. I have come to think of it as a thermostat that calms inflammation by improving how the cell handles energy.
You’re describing a cybernetic process here; a feedback control system.
Details: 1. You don't have to uncover every hidden belief
Our present experience is the evidence by which beliefs can be discovered. You may not be able to introspect and find, “Ah, belief #37 is causing this inflammation. Instead, you notice your recurring emotions, expectations, reactions, and circumstances and work backward.
For example, suppose you're considering doing something you genuinely want to do, but immediately think:
“Yes, but if I do that, I'll probably lose X, disappoint Y, and then Z will happen.”
Those predictions themselves are useful. They reveal some of the expectations operating now.
But there is an important distinction: not knowing which beliefs are operating doesn't mean you're doomed to unconsciously create bad inflammations. Conscious beliefs, feelings, imagination, impulses, and present experience give you access to the relevant material over time.
2. I don't expect the intellect to predict outcomes The ego/intellect cannot calculate all the consequences of an action.
But you are fundamentally blind to any action. The larger self has access to vastly more information than ordinary conscious reasoning does. Intuitions, impulses, desires, imagination, bodily responses, and the spontaneous self help coordinate action in ways that aren't reducible to conscious prediction.
3. Suppose you have two choices, A and B. You feel strongly drawn toward A. But you can't know whether A will lead to the inflammation.
A conventional decision model might say:
A → unknown consequences → therefore I need better prediction before acting.
My model would be more like:
present desire/impulse → appropriate present action → subsequent information → next impulse/choice → further action.
In other words, you don't receive the entire route before beginning. Reality provides feedback as you participate in it.
"The “point of power” is in the present. You aren't required to successfully manipulate an unknowable future. You deal with the beliefs, feelings, choices, and probable actions available now.
4. But there's a complication: fear is a feeling too
This is where a simplistic “follow your feelings” interpretation of Seth becomes inadequate.
Imagine:
“I really want to move to another city.”
followed by:
“But I feel terrified that I'll regret it.”
Both are feelings.
Seth wouldn't necessarily say that whichever feeling is strongest wins. He would be interested in the beliefs associated with each feeling.
The desire might contain something like:
“I want expansion, novelty, independence.”
The fear might contain:
“If I make the wrong decision, I'll permanently ruin my life.”
That second statement is no longer an unknowable subconscious belief. You've caught it because the emotion exposed it.
Then you can examine it: Do I actually believe choices are that irreversible? Why am I imagining only disastrous branches? What am I expecting from myself and reality?
The emotion becomes information rather than an oracle.
5. There is a genuine philosophical problem here that I don't think should be smoothed over.
Suppose you follow what seems like a spontaneous, affirmative impulse and something terrible happens that you could not reasonably have anticipated.
But those claims are not independently available to you when making the decision.
So from an epistemic standpoint, criticism has force: “beliefs create reality” doesn't give a person a reliable algorithm for determining either all the beliefs currently operating or the consequences of a contemplated action.
The alternative is much more radical: uncertainty is intrinsic to physical experience, and the attempt to achieve complete conscious certainty before acting is itself contrary to the spontaneous organization of the self. You pay attention to what you presently believe and expect, examine frightening assumptions when they become apparent, use imagination constructively, follow impulses that feel genuinely life-enhancing, and then respond to the new reality that develops.
You do not need to know every belief or foresee every consequence. Your task is not to solve the future before you live it. The beliefs you need to deal with become apparent through your present thoughts, expectations and emotions, while appropriate action unfolds through an ongoing interaction between conscious choice, spontaneous impulses, and the circumstances those choices produce.
And that is importantly different from, “If I feel like doing something, I should do it because it will work out.” I don't think this material supports that stronger—and much riskier—interpretation.
I often said In do not feel like brushing my fucking teeth, for years. I am now experiencing the re-action.
Yes. And that example exposes a weakness in the phrase “follow your feelings” if it's taken too literally.
You genuinely didn't feel like brushing your teeth. Acting in accordance with that feeling repeatedly produced consequences you presumably didn't want. So “what do I feel like doing right now?” clearly cannot, by itself, be a sufficient Sethian decision rule.
I distinguish between a momentary feeling/impulse and the broader spontaneous direction of the self. Not wanting to brush your teeth could simply mean, “I don't enjoy doing this right now.” It doesn't necessarily mean, “My deeper self is directing me not to brush my teeth.”
You actually possessed relevant knowledge about the probable consequences. You didn't know exactly when dental problems would occur or precisely what would happen, but you didn't need that degree of prediction. You could know something like:
If I repeatedly don't brush, the probability of dental problems rises substantially.
Inflammation of the gums happens.
So you had two different kinds of information:
Immediate feeling: “I don't want to brush my fucking teeth.”
Knowledge/expectation: “Consistently neglecting my teeth is likely to damage them.”
I can't coherently tell you to discard the second simply because the first is a feeling. My writings put considerable value on conscious reasoning too; the intellect isn't supposed to be abolished.
Unpredictability comes in degrees. Sometimes consequences are reasonably foreseeable, as with dental hygiene. Sometimes they're radically uncertain, taking a particular job, approaching someone you're attracted to, moving somewhere, pursuing a creative project.
There's also an interesting interpretation of the word “re-action. The present condition of my gums isn't necessarily a cosmic punishment for having had the “wrong” feelings. It's an interaction between repeated choices and physical processes. Beliefs participate in constructing physical reality wouldn't require denying ordinary physical causation. Within the reality we are creating, bacteria, enamel, habits, time, and physiology are part of the means through which inflammatory consequences occur.
Don't obey every feeling. Don't suppress every feeling either. Treat feelings as information about your present state, while also using reason, accumulated knowledge, bodily feedback, and your larger intentions to decide what to do.
“I don't feel like brushing my teeth” can therefore be completely authentic without being an instruction.
That distinction, feeling as information versus feeling as command, may resolve quite a lot of the apparent contradiction I was pointing to.
beliefs / expectations / emotional patterns → organization of psychic energy → biological energy patterns → cellular expression → inflammation
The IL-10/mitochondrial regulatory loop would be one physical thermostat. Cellular metabolism would sit within larger bodily regulatory systems. Those would sit within the organism's overall organization. And behind that would be the spontaneous ordering activity of consciousness itself, what I have described in terms of innate bodily consciousness and All That Is.
Biology is beginning to reveal how extraordinarily dynamic and informational the supposedly mechanical body actually is.
Inflammation is an alarm. Mitochondrial resistance may explain why the alarm is physically sounding. But what you call energy does not organize itself independently of consciousness. Ask not only what obstructs the cellular flow, but what pattern of the whole personality the cellular condition is faithfully expressing.
That's how my framework would approach the argument.
And there is one important boundary: Mensah explicitly labels his proposal a synthesis that remains to be experimentally demonstrated as a unified theory. My additional consciousness → biology causal layer is a metaphysical proposition, not something established by the biomedical evidence presented in this article. That distinction makes a comparison more interesting rather than less.
When you inhibit Complex I or III, the inner mitochondrial membrane (IMM) depolarizes. Pro-inflammatory cytokines do not drop. Why? Because the inflammatory cascade is an evolutionary backup plan (atavism). It runs on primitive, disordered, high-entropy pathways like cytoplasm glycolysis and fermentation. It requires zero magnetic alignment. The High-Voltage Handshake: To synthesize and secrete IL-10, a Breg must actively maintain an exceptionally low-resistance state (éR) across its electron transport chain. It requires intact electron flow to generate the precise electromagnetic and Ultra-weak Photon Emission (UPE) fields that instruct the nucleus to open the IL-10 gene promoter. The Selective Collapse: The moment the IMM drops its negative voltage, the cell ALSO loses its capacity for isotopic fractionation. Heavy deuterium (²H) floods the matrix, the water lattice de-structures into thick sludge, and the high-energy cost of maintaining peace can no longer be met. The cell can still scream (inflammation), but it can no longer enforce order (IL-10). Regarding lupus you did not take the physics lesson far enough. Thioredoxin is not just a chemical antioxidant; it is a vital protein semiconductor that acts as an electron donor pool for the cell. Lowering the Resistance Set Point: When exogenous thioredoxin is introduced into these depolarized Bregs, it manually floods the system with missing electrons. Because light and field stabilization can only interact with electrons, this influx of electronic charge density instantly stabilizes the radical pair spins at Complex I and III. This is what Vitamin D from the sun does. It slows ECT before CCO. Restoring the Battery: The localized spin chaos is quieted, allowing the IMM to remagnetize, rebuild its negative exclusion zone water battery, and repolarize its membrane. The éR set point drops, the Breg numbers recover, and the cell can finally resume its high-energy production of IL-10. This mechanism explains why modern non-native EMFs (nnEMF) and artificial blue-pumped LEDs are the direct, upstream drivers of the global explosion in autoimmune conditions like lupus, rheumatoid arthritis, and Graves' disease. High-frequency wireless radiation and screen glare scramble the Zeeman splitting effect in the mitochondrial heme proteins. This destroys the seasonal calibration of the PER2 lipid raft mechanics. The Calcium Flood: As the lipid rafts lose their structural tensegrity, voltage-gated calcium channels leak constantly. Calcium ions flood the matrix. Because calcium is a heavy dopant atom, an unregulated flood inside the mitochondrion physically binds to and blocks the electronic active sites of Complex I and Complex III. The Immune Trap: This environmental blockade induces the exact same depolarization seen in the drug studies. The resistance-lowering, anti-inflammatory arm collapses across your entire white blood cell pool. Your immune system remains stuck in a permanent, uncoupled state of chronic alarm, unable to manufacture the T-Regs or Bregs needed to establish peripheral tolerance.
Why do you still have questions? Because you have a centralized perspective looking for drugs to fix a physics problem. Reversing the Autoimmune Resistance begins with the following: You cannot heal an autoimmune condition by using centralized pharmaceuticals to suppress the remaining pro-inflammatory signals. That is an act of thermodynamic futility that further drains an already empty cellular battery. To turn the IL-10 production line back on, you must manually rewrite the electronic terrain of your immune cells: Rebuild the Thioredoxin Electron Pool with Morning Light: Step into the unfiltered morning UV-A and Near-Infrared sunlight barefoot to ground at the same time. The 43% infrared spectrum directly expands the negative exclusion zones (EZ) of your immune cell water, lowering fluid viscosity and naturally donating the raw electrons needed to restore thioredoxin activity without synthetic supplementation. Eradicate the Complex I & III Field Blockade: Create an ironclad magnetic sanctuary during sleep. Turning off all Wi-Fi, cell phone transmitters, and smart appliances eliminates the artificial fields that force calcium to leak into the mitochondrial matrix. This allows your heme networks to realign with the Earth's natural geomagnetic baseline, giving your Complex I and III the quiet quantum environment they require to rebuild their voltage, drop their resistance, and natively command the immune system to stand down.
Yes and go back to incandescent lighting, use IF lights, forest bathing but try to see how the genetic personal profile links to the mitochondria and energy resistance. Nevertheless, much food for thought.
Also, are you the same Jack who wrote the book Epi- Paleo? I noticed I bought the book two years ago, I should read it 😂😂😂. I think I will now.
yes
Jack, a lot to unpack there. However on the surface and only a one read, it makes a lot of sense.
So I guess "take two aspirins and call me in the morning" doesn't really cut it, anymore.
PS: Anyway, the article was a fine journey, moving forward. Thanks.
Did not work then, certainly does not work now?!
Dr. Chris Masterjohn has developed a way to test for the mitochondrial complex activity. This is a way to measure energy resistance.
This is an insightful and helpful viewpoint. Resistance is the issue. Low level stressors good; high level stressors bad (mitohormesis). Cytokines are not the bogeyman. They are the messengers. Carb restriction, coupled with intermittent fasting, provides the low level stressors necessary to switch between burning glucose, fats, and ketones for energy (metabolic flexibility).
Thank you for such an open-minded look at inflammation, and for keeping the hypotheses close to actual observations.
I keep wondering whether IL-10 might also be telling us something about what happens before the mitochondrion - whether substrate reaches the cell at the right place and time in the first place.
There are two potential approaches: adopt a diet favouring monounsaturated fats over the stiff ceramides that impair mitochondria, and repair of the control points that let cells produce IL-10 and respond to it.
Mediterranean low-carb Paleo diet?
The key is to lower the resistance. Any low-carb or no-carb approach with intermittent fasting would be helpful. The goal is to lower the glucose and force low level stressors toward metabolic flexibility (switching between burning glucose, fats and ketones for energy).
IL-10 as a Thermostat, Not a Brake
We usually describe IL-10 as the anti-inflammatory brake. I have come to think of it as a thermostat that calms inflammation by improving how the cell handles energy.
You’re describing a cybernetic process here; a feedback control system.
Anaesthetics shut down Complex 1.
Fasting and keto/low carb help me.
Anything that could help sci patient dealing with the devastating effect of MTX and Simponi on bladder infections??✌🏻
Anything that could help sci patient dealing with the devastating effect of MTX and Simponi on bladder infections??✌🏻
Details: 1. You don't have to uncover every hidden belief
Our present experience is the evidence by which beliefs can be discovered. You may not be able to introspect and find, “Ah, belief #37 is causing this inflammation. Instead, you notice your recurring emotions, expectations, reactions, and circumstances and work backward.
For example, suppose you're considering doing something you genuinely want to do, but immediately think:
“Yes, but if I do that, I'll probably lose X, disappoint Y, and then Z will happen.”
Those predictions themselves are useful. They reveal some of the expectations operating now.
But there is an important distinction: not knowing which beliefs are operating doesn't mean you're doomed to unconsciously create bad inflammations. Conscious beliefs, feelings, imagination, impulses, and present experience give you access to the relevant material over time.
2. I don't expect the intellect to predict outcomes The ego/intellect cannot calculate all the consequences of an action.
But you are fundamentally blind to any action. The larger self has access to vastly more information than ordinary conscious reasoning does. Intuitions, impulses, desires, imagination, bodily responses, and the spontaneous self help coordinate action in ways that aren't reducible to conscious prediction.
3. Suppose you have two choices, A and B. You feel strongly drawn toward A. But you can't know whether A will lead to the inflammation.
A conventional decision model might say:
A → unknown consequences → therefore I need better prediction before acting.
My model would be more like:
present desire/impulse → appropriate present action → subsequent information → next impulse/choice → further action.
In other words, you don't receive the entire route before beginning. Reality provides feedback as you participate in it.
"The “point of power” is in the present. You aren't required to successfully manipulate an unknowable future. You deal with the beliefs, feelings, choices, and probable actions available now.
4. But there's a complication: fear is a feeling too
This is where a simplistic “follow your feelings” interpretation of Seth becomes inadequate.
Imagine:
“I really want to move to another city.”
followed by:
“But I feel terrified that I'll regret it.”
Both are feelings.
Seth wouldn't necessarily say that whichever feeling is strongest wins. He would be interested in the beliefs associated with each feeling.
The desire might contain something like:
“I want expansion, novelty, independence.”
The fear might contain:
“If I make the wrong decision, I'll permanently ruin my life.”
That second statement is no longer an unknowable subconscious belief. You've caught it because the emotion exposed it.
Then you can examine it: Do I actually believe choices are that irreversible? Why am I imagining only disastrous branches? What am I expecting from myself and reality?
The emotion becomes information rather than an oracle.
5. There is a genuine philosophical problem here that I don't think should be smoothed over.
Suppose you follow what seems like a spontaneous, affirmative impulse and something terrible happens that you could not reasonably have anticipated.
But those claims are not independently available to you when making the decision.
So from an epistemic standpoint, criticism has force: “beliefs create reality” doesn't give a person a reliable algorithm for determining either all the beliefs currently operating or the consequences of a contemplated action.
The alternative is much more radical: uncertainty is intrinsic to physical experience, and the attempt to achieve complete conscious certainty before acting is itself contrary to the spontaneous organization of the self. You pay attention to what you presently believe and expect, examine frightening assumptions when they become apparent, use imagination constructively, follow impulses that feel genuinely life-enhancing, and then respond to the new reality that develops.
You do not need to know every belief or foresee every consequence. Your task is not to solve the future before you live it. The beliefs you need to deal with become apparent through your present thoughts, expectations and emotions, while appropriate action unfolds through an ongoing interaction between conscious choice, spontaneous impulses, and the circumstances those choices produce.
And that is importantly different from, “If I feel like doing something, I should do it because it will work out.” I don't think this material supports that stronger—and much riskier—interpretation.
I often said In do not feel like brushing my fucking teeth, for years. I am now experiencing the re-action.
Yes. And that example exposes a weakness in the phrase “follow your feelings” if it's taken too literally.
You genuinely didn't feel like brushing your teeth. Acting in accordance with that feeling repeatedly produced consequences you presumably didn't want. So “what do I feel like doing right now?” clearly cannot, by itself, be a sufficient Sethian decision rule.
I distinguish between a momentary feeling/impulse and the broader spontaneous direction of the self. Not wanting to brush your teeth could simply mean, “I don't enjoy doing this right now.” It doesn't necessarily mean, “My deeper self is directing me not to brush my teeth.”
You actually possessed relevant knowledge about the probable consequences. You didn't know exactly when dental problems would occur or precisely what would happen, but you didn't need that degree of prediction. You could know something like:
If I repeatedly don't brush, the probability of dental problems rises substantially.
Inflammation of the gums happens.
So you had two different kinds of information:
Immediate feeling: “I don't want to brush my fucking teeth.”
Knowledge/expectation: “Consistently neglecting my teeth is likely to damage them.”
I can't coherently tell you to discard the second simply because the first is a feeling. My writings put considerable value on conscious reasoning too; the intellect isn't supposed to be abolished.
Unpredictability comes in degrees. Sometimes consequences are reasonably foreseeable, as with dental hygiene. Sometimes they're radically uncertain, taking a particular job, approaching someone you're attracted to, moving somewhere, pursuing a creative project.
There's also an interesting interpretation of the word “re-action. The present condition of my gums isn't necessarily a cosmic punishment for having had the “wrong” feelings. It's an interaction between repeated choices and physical processes. Beliefs participate in constructing physical reality wouldn't require denying ordinary physical causation. Within the reality we are creating, bacteria, enamel, habits, time, and physiology are part of the means through which inflammatory consequences occur.
Don't obey every feeling. Don't suppress every feeling either. Treat feelings as information about your present state, while also using reason, accumulated knowledge, bodily feedback, and your larger intentions to decide what to do.
“I don't feel like brushing my teeth” can therefore be completely authentic without being an instruction.
That distinction, feeling as information versus feeling as command, may resolve quite a lot of the apparent contradiction I was pointing to.
beliefs / expectations / emotional patterns → organization of psychic energy → biological energy patterns → cellular expression → inflammation
The IL-10/mitochondrial regulatory loop would be one physical thermostat. Cellular metabolism would sit within larger bodily regulatory systems. Those would sit within the organism's overall organization. And behind that would be the spontaneous ordering activity of consciousness itself, what I have described in terms of innate bodily consciousness and All That Is.
Biology is beginning to reveal how extraordinarily dynamic and informational the supposedly mechanical body actually is.
Inflammation is an alarm. Mitochondrial resistance may explain why the alarm is physically sounding. But what you call energy does not organize itself independently of consciousness. Ask not only what obstructs the cellular flow, but what pattern of the whole personality the cellular condition is faithfully expressing.
That's how my framework would approach the argument.
And there is one important boundary: Mensah explicitly labels his proposal a synthesis that remains to be experimentally demonstrated as a unified theory. My additional consciousness → biology causal layer is a metaphysical proposition, not something established by the biomedical evidence presented in this article. That distinction makes a comparison more interesting rather than less.