Thank you. This distinction is necessary 👍 I truly believe your model validates the perceived energy status in so many chronic conditions and hormonal transition phases, and finally gives it a language."
Viewing health and disease through a thermodynamic lens may be one of the most important shifts in medicine. Mitochondrial research is essential here, and the mapping of mitochondrial states and subtypes is valuable work. But I wonder whether “mitotyping” risks repeating a reductionist path: genes, proteins, mitochondria. Energy is not a static property of an organelle but movement through a transport architecture. Are mitochondrial diseases truly diseases of mitochondria — or of the systems they sit within? And is metabolic dysfunction rooted in organelles alone, or in a lifelong biological history shaped by environment, stress, nutrition, movement and systemic load? With the rise of metabolic disease, the key question may be less classification and more flow — where the barriers are, and what creates them.
Mitochondrial diseases here are caused by defects in the mitochondrial energy transformation machinery specifically. So they are properly mitochondrial in origin.
Other factors also can lead to acquired mitochondrial defects.
Thank you. This distinction is necessary 👍 I truly believe your model validates the perceived energy status in so many chronic conditions and hormonal transition phases, and finally gives it a language."
thank you for sharing !
Merci de partager vos recherches aussi fascinantes qu’essentielles.
Viewing health and disease through a thermodynamic lens may be one of the most important shifts in medicine. Mitochondrial research is essential here, and the mapping of mitochondrial states and subtypes is valuable work. But I wonder whether “mitotyping” risks repeating a reductionist path: genes, proteins, mitochondria. Energy is not a static property of an organelle but movement through a transport architecture. Are mitochondrial diseases truly diseases of mitochondria — or of the systems they sit within? And is metabolic dysfunction rooted in organelles alone, or in a lifelong biological history shaped by environment, stress, nutrition, movement and systemic load? With the rise of metabolic disease, the key question may be less classification and more flow — where the barriers are, and what creates them.
Mitochondrial diseases here are caused by defects in the mitochondrial energy transformation machinery specifically. So they are properly mitochondrial in origin.
Other factors also can lead to acquired mitochondrial defects.